Title of article :
5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods Review Article
Author/Authors :
R. Jason Herr، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Pages :
15
From page :
3379
To page :
3393
Abstract :
5-Substituted-1H-tetrazoles (RCN4H) are often used as metabolism-resistant isosteric replacements for carboxylic acids (RCO2H) in SAR-driven medicinal chemistry analogue syntheses. This review provides a brief summary of the medicinal chemistry of tetrazolic acids and highlights some examples of tetrazole-containing drug substances in the current literature. A survey of representative literature procedures for the preparation of 5-substituted-1H-tetrazoles, focusing on preparations from aryl and alkyl nitriles, is presented in sections by generalized synthetic methods.
Journal title :
Bioorganic and Medicinal Chemistry
Serial Year :
2002
Journal title :
Bioorganic and Medicinal Chemistry
Record number :
1302412
Link To Document :
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