Title of article :
Quantitative structure–Activity relationship studies on 5-phenyl-3-ureido-1,5-benzodiazepine as cholecystokinin-A receptor antagonists Original Research Article
Author/Authors :
Vijay K. Agrawal، نويسنده , , Ruchi Sharma and P. V. Khadikar ، نويسنده , , Keshav C. Mathur and Padmakar V. Khadikar، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Pages :
11
From page :
3571
To page :
3581
Abstract :
Quantitative structure–activity relationship (QSAR) studies on a series of 5-phenyl-3-ureido-1,5-benzodiazepine-2,4-diones has been carried out using a pool of distance-based topological indices. Step-wise regression analysis indicated that penta-parametric regression expression containing Sz, B, Ip1, Ip2 and Ip3 is the most potent and selective for CCK-A affinity. The predictive potential of the model is discussed on the basis of cross-validation parameters as well as by estimating root mean square (RMSR) of the residuals.
Journal title :
Bioorganic and Medicinal Chemistry
Serial Year :
2002
Journal title :
Bioorganic and Medicinal Chemistry
Record number :
1302433
Link To Document :
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