Title of article
Highly potent inhibitors of TNF-α production. Part I: Discovery of new chemical leads and Their structure–Activity relationships Original Research Article
Author/Authors
Toshiaki Matsui، نويسنده , , Takashi Kondo، نويسنده , , Yoshitaka Nishita، نويسنده , , Satoshi Itadani، نويسنده , , Shingo Nakatani، نويسنده , , Nagashige Omawari، نويسنده , , Masaru Sakai، نويسنده , , Shuichi Nakazawa، نويسنده , , Akihito Ogata، نويسنده , , Hideaki Mori، نويسنده , , Kouichiro Terai، نويسنده , , Wataru Kamoshima، نويسنده , , Hiroyuki Ohno، نويسنده , , Takaaki Obata، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
30
From page
3757
To page
3786
Abstract
Discovery of new chemical leads of inhibitors for TNF-α production starting from the chemical modification of 1 is reported. Further biological studies of 1 to disclose the site of its action strongly suggested that 1 inhibits LPS-induced TNF-α expression in the liver and spleen of mice. Structure–activity relationships (SARs) are also discussed and full details including the chemistry are reported.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2002
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302453
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