• Title of article

    Highly potent inhibitors of tnf-α production. Part II: metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer Original Research Article

  • Author/Authors

    Toshiaki Matsui، نويسنده , , Takashi Kondo، نويسنده , , Yoshitaka Nishita، نويسنده , , Satoshi Itadani، نويسنده , , Hiroshi Tsuruta، نويسنده , , Setsuko Fujita، نويسنده , , Nagashige Omawari، نويسنده , , Masaru Sakai، نويسنده , , Shuichi Nakazawa، نويسنده , , Akihito Ogata، نويسنده , , Hideaki Mori، نويسنده , , Wataru Kamoshima، نويسنده , , Kouichiro Terai، نويسنده , , Hiroyuki Ohno، نويسنده , , Takaaki Obata، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2002
  • Pages
    19
  • From page
    3787
  • To page
    3805
  • Abstract
    Design and synthesis of metabolically stabilized inhibitors of TNF-α production, which could be new drug candidates, are reported. Conformational analysis of an active diastereoisomer was performed based on biological evaluations of the conformationally fixed indane derivatives 17 and 18. Structure–activity relationships (SARs) based on biological evaluations of the optically active derivatives are also discussed. Full details including chemistry are reported.
  • Journal title
    Bioorganic and Medicinal Chemistry
  • Serial Year
    2002
  • Journal title
    Bioorganic and Medicinal Chemistry
  • Record number

    1302454

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1302454