Author/Authors :
Ishwar Singh، نويسنده , , Ashok K. Prasad، نويسنده , , Ajendra K Sharma، نويسنده , , Rajendra Kumar Saxena، نويسنده , , Carl E Olsen، نويسنده , , Ashok L Cholli، نويسنده , , Lynne A. Samuelson، نويسنده , , Jayant Kumar، نويسنده , , Arthur C Watterson، نويسنده , , Virinder S. Parmar، نويسنده ,
Abstract :
Eleven (±)-5/6/7-acetoxy-4-aryl-3,4-dihydrocoumarins have been synthesised in two steps starting from the coupling of cinnamic acid/substituted cinnamic acid with appropriate phenols, followed by acetylation in 50–83% overall yields. All hydroxy- and acetoxycoumarins were unambiguously identified on the basis of their spectral data. Candida antarctica lipase-catalysed deacetylation of these racemic acetoxydihydrocoumarins in dioxane occurred with moderate enantioselectivity. This is one of the rare examples of resolution using phenolic ester moiety as a remote handle for chiral recognition by a lipase.