Title of article :
Synthesis and bioactivity of 4,10-dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid and its esters Original Research Article
Author/Authors :
Qian Zhang، نويسنده , , Ying Chen، نويسنده , , Yun-Qing Zheng، نويسنده , , Peng-Xia Liu، نويسنده , , Yi Xia، نويسنده , , Zheng Yu Yang، نويسنده , , Kenneth F. Bastow، نويسنده , , Susan L. Morris-Natschke، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Abstract :
4,10-Dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid (1) was synthesized by a new approach via the key intermediate 7-[1-aza-2-(dimethylamino)vinyl]-4-methylquinolin-2(1H)-one (4). Compound 1 and its esters were evaluated in cytotoxicity and anti-HIV assays. The 9-carboxyl (1s)-endo-(−)-borneol ester (9) showed marginal cytotoxic activity in CAK1-1, HOS, KB, and HCT-8 cells.
