Title of article
Semi-Synthesis of an O-Glycosylated docetaxel analogue Original Research Article
Author/Authors
Anastasia Nikolakakis، نويسنده , , Khadidja Haidara، نويسنده , , Françoise Sauriol، نويسنده , , Orval Mamer، نويسنده , , Lolita O Zamir، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
6
From page
1551
To page
1556
Abstract
A 7β-O-glycosylated docetaxel analogue was semi-synthesized from 9-dihydro-13-acetylbaccatin III, the most abundant taxane isolated from the needles of Taxus canadensis. It was shown to be more bioactive than paclitaxel according to the tubulin assay. It had a reduced potency in the MCF7 cell line cytotoxicity assay compared to paclitaxel, but it demonstrated better activity against the drug resistant cell line MCF7-ADR. In addition, the presence of one sugar moiety on C-7 doubled the water solubility versus that of paclitaxel.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2003
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302641
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