Title of article
Synthesis of a biotin-tagged photoaffinity probe of 2-azetidinone cholesterol absorption inhibitors Original Research Article
Author/Authors
Wendelin Frick، نويسنده , , Andrea Bauer-Sch?fer، نويسنده , , Jochen Bauer، نويسنده , , Frank Girbig، نويسنده , , Daniel Corsiero، نويسنده , , Hubert Heuer، نويسنده , , Werner Kramer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1639
To page
1642
Abstract
The design and synthesis of a biotin-tagged photoreactive analogue C-4 of the cholesterol absorption inhibitor Ezetimibe is described. Photoaffinity labeling of intestinal brush border membrane vesicles with C-4 and subsequent streptavidin–biotin chromatography leads to selective extraction of a 145 kDa integral membrane protein as the molecular target for cholesterol absorption inhibitors.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2003
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302650
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