Author/Authors :
Masanao Inagaki، نويسنده , , Hirokuni Jyoyama، نويسنده , , Takashi Ono، نويسنده , , Katsutoshi Yamada، نويسنده , , Mika Kobayashi، نويسنده , , Takahiko Baba، نويسنده , , Akira Touchi، نويسنده , , Kouji Iwatani، نويسنده , , Tomoyuki Ohkawa، نويسنده , , Saichi Matsumoto، نويسنده , , Tatsuo Tsuri، نويسنده ,
Abstract :
We have synthesized and characterized some oxidative metabolites of S-2474. In this study, we discovered a novel skeleton, the 2,3-dihydrobenzofuran derivative, which inhibited PGE2 production at a very low concentration and was effective in the anti-carrageenin footpad edema assay.
