Title of article :
Superoxide dismutase mimetics. Part 2: synthesis and structure–Activity relationship of glyoxylate- and glyoxamide-Derived metalloporphyrins Original Research Article
Author/Authors :
Michael P. Trova، نويسنده , , Polivina Jolicia F Gauuan، نويسنده , , Anthony D. Pechulis، نويسنده , , Stephen M Bubb، نويسنده , , Stephen B Bocckino، نويسنده , , James D. Crapo، نويسنده , , Brian J. Day، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
Novel glyoxylate- and glyoxamide-derived metalloporphyrins 26–58 were synthesized and evaluated as potential superoxide dismutase (SOD) mimetics. Relative to previously studied MnTBAP analogues, the glyoxylate-derived metalloporphyrins 32, 39, and 54 and glyoxamide-derived metalloporphyrin 49, exhibited enhanced activity in the SOD assay and the majority of the analogues in the current series showed enhanced inhibition of lipid peroxidation and catalase activity.
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
