Author/Authors :
Thomas Rühl، نويسنده , , Mohammed Daghish، نويسنده , , Andrij Buchynskyy، نويسنده , , Karen Barche، نويسنده , , Daniela Volke، نويسنده , , Katherina Stembera، نويسنده , , Uwe Kempin، نويسنده , , Dietmar Knoll، نويسنده , , Lothar Hennig، نويسنده , , Matthias Findeisen، نويسنده , , Ramona Oehme، نويسنده , , Sabine Giesa، نويسنده , , Juan Ayala، نويسنده , , Peter Welzel، نويسنده ,
Abstract :
The interaction of a moenomycin derivative with the enzyme penicillin binding protein 1b (PBP 1b) has been studied by means of STD NMR. The results obtained initiated the synthesis of a number of moenomycin derivatives modified in unit A including a moenomycin–ampicillin conjugate and determination of their antibiotic activities. A protocol is described that allows studying the interaction of moenomycin analogues with PBP 1b by fluorescence correlation spectroscopy.
