Title of article
Discovery of novel modulators of metabotropic glutamate receptor subtype-5 Original Research Article
Author/Authors
Bowei Wang، نويسنده , , Jean-Michel Vernier، نويسنده , , Sara Rao، نويسنده , , Janice Chung، نويسنده , , Jeffery J Anderson، نويسنده , , Jesse D Brodkin، نويسنده , , Xiaohui Jiang، نويسنده , , Michael F Gardner، نويسنده , , Xiaoqing Yang، نويسنده , , Benito Munoz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
17
To page
21
Abstract
A series of potent and selective mGluR5 antagonists were synthesized and evaluated in vitro and in vivo. It was found that a pyridyl functionality is a potential replacement for acetonitrile in the lead structure, with 2-pyridyl being most favored. Additionally, the benzoxazole moiety could also be replaced by other heterobicyclic rings such as imidazothiazole.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302835
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