Author/Authors :
Bowei Wang، نويسنده , , Jean-Michel Vernier، نويسنده , , Sara Rao، نويسنده , , Janice Chung، نويسنده , , Jeffery J Anderson، نويسنده , , Jesse D Brodkin، نويسنده , , Xiaohui Jiang، نويسنده , , Michael F Gardner، نويسنده , , Xiaoqing Yang، نويسنده , , Benito Munoz، نويسنده ,
Abstract :
A series of potent and selective mGluR5 antagonists were synthesized and evaluated in vitro and in vivo. It was found that a pyridyl functionality is a potential replacement for acetonitrile in the lead structure, with 2-pyridyl being most favored. Additionally, the benzoxazole moiety could also be replaced by other heterobicyclic rings such as imidazothiazole.
