Title of article
Combining NMR and molecular modelling in a drug delivery context: investigation of the multi-mode inclusion of a new NPY-5 antagonist bromobenzenesulfonamide into β-cyclodextrin Original Research Article
Author/Authors
Gloria Uccello Barretta، نويسنده , , Federica Balzano، نويسنده , , Giuseppe Sicoli، نويسنده , , Carmen Fr??glola، نويسنده , , Ignacio Aldana، نويسنده , , Antonio Monge، نويسنده , , Donatella Paolino، نويسنده , , Salvatore Guccione، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
12
From page
447
To page
458
Abstract
NMR spectroscopic and molecular modelling methods have been employed to describe the complexation of trans-N-4-[N′-(4-chlorobenzoyl)hydrazinocarbonyl]cyclohexylmethyl-4-bromobenzenesulfonamide, a new chemotype of NPY-5 antagonist, and β-cyclodextrin, revealing the coexistence of two different kinds of 1:1 complexes where conformational changes of the guest compound with respect to the free state are also detected
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302878
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