Author/Authors :
Khalid Mohammed Khan، نويسنده , , Sajid Iqbal، نويسنده , , Muhammad Arif Lodhi، نويسنده , , Ghulam Murtaza Maharvi، نويسنده , , Zia- Ullah، نويسنده , , Muhammad Iqbal Choudhary، نويسنده , , Atta-ur- Rahman، نويسنده , , Shahnaz Perveen، نويسنده ,
Abstract :
A variety of biscoumarins (1–21) with variable substituents at C-11 were synthesized with an improved method and evaluated as urease inhibitors. The synthesized compounds showed varying degree of urease inhibitory activity ranging from 15.06–91.35 μM. The size and electron donating or withdrawing effects of substituents influenced the activity, which lead to the urease inhibitors.
