Title of article
Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii Original Research Article
Author/Authors
Katarzyna Kopa?ska (née Zast?pi?o)، نويسنده , , Andzelika Najda، نويسنده , , Justyna ?ebrowska، نويسنده , , Lidia Chomicz، نويسنده , , Janusz Piekarczyk، نويسنده , , Przemys?aw Myjak، نويسنده , , Maria Bretner، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
8
From page
2617
To page
2624
Abstract
Chloro-, bromo- and methyl- analogues of 1H-benzimidazole and 1H-benzotriazole and their N-alkyl derivatives have been synthesized and tested in vitro against the protozoa Acanthamoeba castellanii. The results indicate that 5,6-dimethyl-1H-benzotriazole (11) and 5,6-dibromo-1H-benzotriazole (14) have higher efficacy than the antiprotozoal agent chlorohexidine.
Keywords
Analogues of 1H-benzimidazole , Antiprotozoal activity , Acanthamoeba castellanii , Analogues of 1H-benzotriazole
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303068
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