Title of article
Design and synthesis of chromogenic thiopeptolide substrates as MetAPs active site probes Original Research Article
Author/Authors
Yong-Mei Cui، نويسنده , , Jing-Ya Li، نويسنده , , Ling-Ling Chen، نويسنده , , Jia Li، نويسنده , , Qizhuang Ye، نويسنده , , Fa-Jun Nan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
9
From page
2853
To page
2861
Abstract
Twenty one chromogenic thiopeptolide substrates were designed and synthesized as the active site probes and analyzed with each S1 site of mutant residues and enzymes of wild-type MetAP1s. The preliminary enzymatic experiments indicate that cysteine 70 or 202, at either Escherichia coli or human MetAP1, played a crucial role in the methionine hydrolysis.
Keywords
Chromogenic thiopeptolide substrates , Methionine aminopeptidases
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303091
Link To Document