Title of article
Synthesis and antiangiogenic activity of thioacetal artemisinin derivatives Original Research Article
Author/Authors
Sangtae Oh، نويسنده , , In Howa Jeong، نويسنده , , Chan Mug Ahn، نويسنده , , Woon-Seob Shin، نويسنده , , Seokjoon Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
8
From page
3783
To page
3790
Abstract
Various thioacetal artemisinin derivatives can inhibit the angiogenesis and might be angiogenesis inhibitors. In particular, 10α-phenylthiodihydroartemisinins (5), 10β-benzenesulfonyl-9-epi-dihydroartemisinin (11) and 10α-mercaptodihydroartemisinin (13) exhibit strong growth inhibition activity against HUVEC proliferation. Compound 11 have a good inhibitiory activity upon HUVEC tube formation, and 5 and 11 show a strong inhibitory effect on angiogenesis using CAM assay at 5 μg/egg by 90%.
Keywords
Angiogenesis , Antiangiogenesis , Artemisinin , Thioacetal artemisinin
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303158
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