Title of article
Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum Original Research Article
Author/Authors
Hong-Ji Ma and Rui Nie، نويسنده , , Shannon H Jones، نويسنده , , Sidney M. Hecht and Stewart Shuman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
3885
To page
3889
Abstract
In a survey of the active components of crude plant extracts for their ability to cleave DNA, a crude extract prepared from Piper caninum was found to induce the relaxation of supercoiled pBR322 plasmid DNA in the presence of Cu2+. Bioassay-guided fractionation was carried out on this extract, guided by an in vitro DNA strand scission assay. Three active principles were isolated and identified as N-cis-feruloyl tyramine (1),N-trans-feruloyl tyramine (2), and 1-cinnamoylpyrrolidine (3). Compounds 1–3 represent a structurally new type of DNA strand scission agent.
Keywords
Nucleic acids , Chemotherapy , Natural products
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303169
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