Title of article
Development of prostaglandin D2 receptor antagonist: discovery of highly potent antagonists Original Research Article
Author/Authors
Kazuhiko Torisu، نويسنده , , Kaoru Kobayashi، نويسنده , , Maki Iwahashi، نويسنده , , Yoshihiko Nakai، نويسنده , , Takahiro Onoda، نويسنده , , Toshihiko Nagase، نويسنده , , Isamu Sugimoto، نويسنده , , Yutaka Okada، نويسنده , , Ryoji Matsumoto، نويسنده , , Fumio Nanbu، نويسنده , , Shuichi Ohuchida، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
16
From page
4685
To page
4700
Abstract
The process of discovery for highly potent prostaglandin D2 (PGD2) receptor antagonists is reported. A series of N-(p-alkoxy)benzoyl-2-methylindole-4-acetic acids were synthesized and identified as a new class of selective PGD2 receptor antagonists. Most of them exhibited strong PGD2 receptor antagonism in binding studies and the cAMP formation assay. The structure–activity relationships (SAR), including subtype selectivity of the synthesized compounds, are also discussed.
Keywords
DP receptor , Prostaglandin , Antagonist
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303238
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