Title of article
Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA–FtsZ interaction Original Research Article
Author/Authors
Lee D. Jennings، نويسنده , , Kenneth W. Foreman، نويسنده , , Thomas S. Rush III، نويسنده , , Desiree H.H. Tsao، نويسنده , , Lidia Mosyak، نويسنده , , Scott L. Kincaid، نويسنده , , Mohani N. Sukhdeo، نويسنده , , Alan G. Sutherland، نويسنده , , Weidong Ding، نويسنده , , Cynthia Hess Kenny، نويسنده , , Chantel L. Sabus، نويسنده , , Hanlan Liu، نويسنده , , Elizabeth G. Dushin، نويسنده , , Soraya L. Moghazeh، نويسنده , , Pornpen Labthavikul، نويسنده , , Peter J. Petersen، نويسنده , , Margareta Tuckman، نويسنده , , Alexey V. Ruzin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
17
From page
5115
To page
5131
Abstract
The ZipA–FtsZ protein–protein interaction is a potential target for antibacterial therapy. The design and parallel synthesis of a combinatorial library of small molecules, which target the FtsZ binding area on ZipA are described. Compounds were demonstrated to bind to the FtsZ binding domain of ZipA by HSQC NMR and to inhibit cell division in a cell elongation assay.
Keywords
ZipA , FtsZ , Bacterial cell division , protein–protein interaction , Antiinfectives
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303279
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