Title of article
Novel selective and potent 5-HT reuptake inhibitors with 5-HT1D antagonist activity: chemistry and pharmacological evaluation of a series of thienopyran derivatives Original Research Article
Author/Authors
Alicia Torrado، نويسنده , , Carlos Lamas، نويسنده , , Javier Agejas، نويسنده , , Alma Jimenez، نويسنده , , Nuria D??az، نويسنده , , Jeremy Gilmore، نويسنده , , John Boot، نويسنده , , Jeremy Findlay، نويسنده , , Lorna Hayhurst، نويسنده , , Louise Wallace، نويسنده , , Richard Broadmore، نويسنده , , Rosemarie Tomlinson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
19
From page
5277
To page
5295
Abstract
A series of compounds combining the naphthylpiperazine and thienopyran scaffolds has been prepared and evaluated for 5-HT reuptake inhibition with 5-HT1D antagonist activity. The design of these compounds has been based on the ‘overlapping type’ strategy where two pharmacophores are linked in a single molecule. The resultant dual pharmacological profile has the potential to deliver a more efficient treatment for depression.
Keywords
5-HT1D Antagonist , Thienopyran scaffold , 5-HT Reuptake inhibitor
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303293
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