Title of article
Synthesis and antihyperglycemic activity profiles of novel thiazolidinedione derivatives Original Research Article
Author/Authors
Bashir A. Bhat، نويسنده , , Shashikanth Ponnala، نويسنده , , Devi Prasad Sahu، نويسنده , , Priti Tiwari، نويسنده , , Brajendra K. Tripathi، نويسنده , , Arvind K. Srivastava، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
8
From page
5857
To page
5864
Abstract
A number of thiazolidine-2,4-diones derivatives having carboxylic ester appendage at N-3 were synthesized and their antihyperglycemic activity was evaluated. Many of these derivatives as well as their corresponding carboxylic acid showed significant improvement on post-prandial hyperglycemia in normal rats, in contrast to their poor agonist activity at PPARγ.
Keywords
Antihyperglycemic activity , Thiazolidinedione , Diabetes , SLM , PPAR?
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303344
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