Title of article
Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies Original Research Article
Author/Authors
Alejandra Gerpe، نويسنده , , Gabriela Aguirre، نويسنده , , Luc?a Boiani، نويسنده , , Hugo Cerecetto، نويسنده , , Mercedes Gonzalez-Wangüemert، نويسنده , , Claudio Olea-Azar، نويسنده , , Carolina Rigol، نويسنده , , Juan D. Maya، نويسنده , , Antonio Morello، نويسنده , , Oscar E. Piro، نويسنده , , Vicente J. Ar?n، نويسنده , , Amaia Azqueta، نويسنده , , Adela L?pez de Cer?in، نويسنده , , Antonio Monge، نويسنده , , Mar?a Antonieta Rojas، نويسنده , , Gloria Yaluff، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
14
From page
3467
To page
3480
Abstract
A series of indazole N-oxide derivatives have been synthesized and their antichagasic and leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N1-oxide exhibited interesting antichagasic activity on the two parasitic strains and the two parasitic stages evaluated. Furthermore, besides its trypanocidal activity, 3-cyano-2-(4-nitrophenyl)-2H-indazole N1-oxide showed leishmanocidal activity in the three parasitic strains evaluated. To gain insight into the mechanism of action, electrochemical behaviour, ESR experiment, inhibition of parasitic respiration and QSAR were performed.
Keywords
Indazole N-oxide , Antichagasic activity , Leishmanocidal activity
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303410
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