Author/Authors :
Wayne L. Cody، نويسنده , , Daniel D. Holsworth، نويسنده , , Noel A. Powell، نويسنده , , Mehran Jalaie، نويسنده , , Erli Zhang، نويسنده , , Wei Wang، نويسنده , , Brian Samas، نويسنده , , john bryant، نويسنده , , Robert Ostroski، نويسنده , , MICHAEL J. RYAN، نويسنده , , Jeremy J. Edmunds، نويسنده ,
Abstract :
Recently, trans-disubstituted oxo-aryl-piperidines have been identified as small molecule nonpeptide renin inhibitors for the modulation of hypertension. Herein, we report on the discovery and preparation of a new class of novel cis-disubstituted amino-aryl-piperidines as a mixture of enantiomers that are potent in vitro renin inhibitors and also, possess in vivo antihypertensive activity in a double transgenic mouse model.
