Title of article
α-cycloalkyl-substituted ω-keto-dicarboxylic acids as lipid regulating agents Original Research Article
Author/Authors
Roel P.L. Bell، نويسنده , , Dennis Verdijk، نويسنده , , Mike Relou، نويسنده , , Dennis Smith، نويسنده , , Henk Regeling، نويسنده , , Eelco J. Ebbers، نويسنده , , Frank M. C. Leemhuis، نويسنده , , Daniela C. Oniciu، نويسنده , , Clay T. Cramer، نويسنده , , Brian Goetz، نويسنده , , Michael E. Pape، نويسنده , , Brian R. Krause، نويسنده , , Jean-Louis Dasseux، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
14
From page
223
To page
236
Abstract
A series of cycloalkyl-substituted oxo-alkanedicarboxylic acids have been prepared by the TosMIC methodology departing from haloalkyl-substituted cycloalkylcarboxylic esters. cyclopropyl derivatives showed IC50 activity in the 0.3–1.0 μM range on the de novo incorporation of radiolabeled acetate into lipids in primary cultures of rat hepatocytes, and they showed lipid-regulating properties when tested in vivo in female obese Zucker fatty rats.
Keywords
Dyslipidemia , HDL-cholesterol , Cycloalkyl , TosMIC
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303472
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