Author/Authors :
Roel P.L. Bell، نويسنده , , Dennis Verdijk، نويسنده , , Mike Relou، نويسنده , , Dennis Smith، نويسنده , , Henk Regeling، نويسنده , , Eelco J. Ebbers، نويسنده , , Frank M. C. Leemhuis، نويسنده , , Daniela C. Oniciu، نويسنده , , Clay T. Cramer، نويسنده , , Brian Goetz، نويسنده , , Michael E. Pape، نويسنده , , Brian R. Krause، نويسنده , , Jean-Louis Dasseux، نويسنده ,
Abstract :
A series of cycloalkyl-substituted oxo-alkanedicarboxylic acids have been prepared by the TosMIC methodology departing from haloalkyl-substituted cycloalkylcarboxylic esters. cyclopropyl derivatives showed IC50 activity in the 0.3–1.0 μM range on the de novo incorporation of radiolabeled acetate into lipids in primary cultures of rat hepatocytes, and they showed lipid-regulating properties when tested in vivo in female obese Zucker fatty rats.
Keywords :
Dyslipidemia , HDL-cholesterol , Cycloalkyl , TosMIC
