Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase Original Research Article

Tie2 kinase, an enzyme that supports angiogenesis essential for tumor growth and survival, was selected as a target in a search for naturally occurring inhibitors of potential utility for antitumor therapy. Two polybrominated diphenyl ethers, 3,5-dibromo-2-(2′,4′-dibromophenoxy)phenol (1) and 4,6-dibromo-2-(2′,4′-dibromophenoxy)phenol (2) were isolated from an extract prepared from Dysidea sp. after bioassay-guided fractionation.