Title of article
Synthesis of multisubstituted quinolines from Baylis–Hillman adducts obtained from substituted 2-chloronicotinaldehydes and their antimicrobial activity Original Research Article
Author/Authors
P. Narender، نويسنده , , U. Srinivas، نويسنده , , M. Ravinder Reddy، نويسنده , , B. Ananda Rao، نويسنده , , Ch. Ramesh، نويسنده , , K. Harakishore، نويسنده , , B. Gangadasu، نويسنده , , U.S.N. Murthy، نويسنده , , M. Janaki Ram Reddy and V. Jayathirtha Rao، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
10
From page
4600
To page
4609
Abstract
Baylis–Hillman acetates were synthesized from substituted 2-chloronicotinaldehydes and were conveniently transformed into multisubstituted quinolines and cyclopenta[g]quinolines on reaction with nitroethane or ethyl cyanoacetate via a successive SN2′–SNAr elimination strategy. Thus, synthesized quinolines were evaluated for antimicrobial activity and found having substantial antibacterial and antifungal activity.
Keywords
Antimicrobial evaluation , Substituted 2-chloronicotinaldehydes , Baylis–Hillman adducts , SN2?–SNAr elimination reaction , Multisubstituted quinolines
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303632
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