Author/Authors :
Taro Terauchi، نويسنده , , Naoki Asai، نويسنده , , Takashi Doko، نويسنده , , Ryota Taguchi، نويسنده , , OSAMU TAKENAKA، نويسنده , , Hideki Sakurai، نويسنده , , Masahiro Yonaga، نويسنده , , Teiji Kimura، نويسنده , , Akiharu Kajiwara، نويسنده , , Tetsuhiro Niidome، نويسنده , , Toshiaki Kume، نويسنده , , Akinori Akaike، نويسنده , , Hachiro Sugimoto، نويسنده ,
Abstract :
We present efficient syntheses of serofendic acids A and B (SA-A and SA-B), novel neuroprotective substances isolated from fetal calf serum. Biological and pharmacological evaluation showed that SA-A and SA-B have potent protective action against glutamate-induced neurotoxicity, but do not interact directly with glutamate receptors. A pharmacokinetic study showed that they have good oral bioavailability in rats. The results indicate that SA-A and SA-B are potential lead compounds for candidate drugs to treat various neurological disorders.
Keywords :
Neuroprotective , Neurodegenerative disease , Atisane , Glutamate , Neurotoxicity , Serofendic acid
