Title of article
Mimetics of the tri- and tetrasaccharide epitope of GQ1bα as myelin-associated glycoprotein (MAG) ligands Original Research Article
Author/Authors
Ganpan Gao، نويسنده , , Martin Smiesko، نويسنده , , Oliver Schwardt، نويسنده , , Heiko G?thje، نويسنده , , Soerge Kelm، نويسنده , , Angelo Vedani، نويسنده , , Beat Ernst، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
11
From page
7459
To page
7469
Abstract
The synthesis of phenoxyphenyl, phenoxybenzyl, biphenyl, and phenyltriazole substituted sialic acid derivatives as mimics of the tri- and tetrasaccharide epitopes of GQ1bα is described. These synthetically easily available sialosides show comparable or even enhanced affinity to MAG compared with the natural tri- and tetrasaccharide epitopes and form a new class of potential MAG antagonists.
Keywords
MAG , GQ1b? , Affinity , Carbohydrate mimetics , Suzuki coupling
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303833
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