Title of article
Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14α-demethylase (CYP51) Original Research Article
Author/Authors
Tina Koro?ec، نويسنده , , Jure Acimovic، نويسنده , , Matej Seli?kar، نويسنده , , Darko Kocjan، نويسنده , , Klementina Fon Tacer، نويسنده , , Damjana Rozman، نويسنده , , Uros Urleb، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
13
From page
209
To page
221
Abstract
Novel cholesterol biosynthesis inhibitors, a group of pyridylethanol(phenylethyl)amine derivatives, were synthesized. Sterol profiling assay in the human hepatoma HepG2 cells revealed that compounds target human lanosterol 14α-demethylase (CYP51). Structure–activity relationship study of the binding with the overexpressed human CYP51 indicates that the pyridine binds within the heme binding pocket in an analogy with the azoles.
Keywords
DPP-IV inhibitor , N-(Cyanomethyl)-N-alkyl-l-prolinamide , Prolyl-2-cyanopyrrolidine
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303893
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