Title of article
Structure–activity relationships of novel HIV-1 protease inhibitors containing the 3-amino-2-chlorobenzoyl-allophenylnorstatine structure Original Research Article
Author/Authors
Tsutomu Mimoto، نويسنده , , Satoshi Nojima، نويسنده , , Keisuke Terashima، نويسنده , , Haruo Takaku، نويسنده , , Makoto Shintani، نويسنده , , Hideya Hayashi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
10
From page
1299
To page
1308
Abstract
A series of peptidomimetic human immunodeficiency virus (HIV) protease inhibitors containing substituted allophenylnorstatine (Apns: (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid) were designed and synthesized. From the structure–activity relationship of this series of compounds, SM-309515 was found to have potent antiviral activity against wild-type and resistant HIV-1s and to possess a desirable pharmacokinetic profile in dogs.
Keywords
HIV , Protease , Inhibitor , SM-309515
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303994
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