Title of article
Alachalasins A–G, new cytochalasins from the fungus Stachybotrys charatum Original Research Article
Author/Authors
Yonggang Zhang، نويسنده , , Renrong Tian، نويسنده , , Shuchun Liu، نويسنده , , Xulin Chen، نويسنده , , Xingzhong Liu، نويسنده , , Yongsheng Che، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
8
From page
2627
To page
2634
Abstract
Alachalasins A–G (1–7), seven new cytochalasin-type of metabolites, have been isolated from cultures of an isolate of Stachybotrys charatum. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data, and the absolute configuration of 1 was assigned by application of the modified Mosher method. Alachalasin A (1) displayed inhibitory effect on HIV-1LAI replication in C8166 cells with an EC50 of 8.01 μM; alachalasins D (4) and G (7) showed modest antimicrobial activity.
Keywords
Stachybotrys charatum , Alachalasins , Anti-HIV , Antibacterial
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304098
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