Title of article
Novel 1,3,4-thiadiazolium-2-phenylamine chlorides derived from natural piperine as trypanocidal agents: Chemical and biological studies Original Research Article
Author/Authors
Welisson da Silva Ferreira، نويسنده , , Leonardo Freire-de-Lima، نويسنده , , V?ctor Barbosa Saraiva، نويسنده , , Frederico Alisson-Silva، نويسنده , , Lucia Mendonça-Previato، نويسنده , , José Osvaldo Previato، نويسنده , , Aurea Echevarria، نويسنده , , Marco Edilson Freire de Lima، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
8
From page
2984
To page
2991
Abstract
We herein describe the synthesis and characterization of nine new 1,3,4-thiadiazolium-2-phenylamine chlorides derived from natural piperine. We evaluate their toxic effects against the different evolutive forms of Trypanosoma cruzi, and the host cell (murine macrophages). The results obtained show that mesoionic hydrochloride MI possesses the best activity profile. Compound MI may be a prototype for use in the development of a new chemotherapeutic agent with high efficiency, which may be employed in the treatment of Chagas’ disease.
Keywords
CCK , CCK2 , Gastrin , Benzotriazepine , Antagonist
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304132
Link To Document