Title of article
Inhibition of 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors Original Research Article
Author/Authors
Urmi Dhagat، نويسنده , , Satoshi Endo، نويسنده , , Akira Hara and Yukio Mitsui، نويسنده , , Ossama El-Kabbani، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
10
From page
3245
To page
3254
Abstract
Mouse 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) is a member of the aldo-keto reductase superfamily that catalyses the oxido-reduction of steroid hormones such as estrogens, androgens and neurosteroids. Inhibitors of aldose reductase (AR), a member of the same superfamily, were evaluated against AKR1C21. Models of the enzyme–inhibitor complexes suggest that Tyr118 and Phe311 are important residues for inhibitor recognition and orientation in the active site of AKR1C21.
Keywords
drug design , Hydroxysteroid dehydrogenases , Aldose reductase , Enzyme inhibition , Molecular modeling , Aldo-keto reductases
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304157
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