Title of article
Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme Original Research Article
Author/Authors
Eui Seok Shin، نويسنده , , Jiyoung Park، نويسنده , , Jae-Min Shin، نويسنده , , Dooho Cho، نويسنده , , Si Young Cho، نويسنده , , Dong Wook Shin، نويسنده , , Mira Ham، نويسنده , , Jae Bum Kim، نويسنده , , Tae Ryong Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
3580
To page
3586
Abstract
Recent studies have shown that glucose-6-phosphate dehydrogenase (G6PD) is an effectual therapeutic target for metabolic disorders, including obesity and diabetes. In this study, we used in silico and conventional screening approaches to identify putative inhibitors of G6PD and found that gallated catechins (EGCG, GCG, ECG, CG), but not ungallated catechins (ECG, GC, EC, C), were NADP+-competitive inhibitors of G6PD and other enzymes that employ NADP+ as a coenzyme, such as IDH and 6PGD.
Keywords
Isocitrate dehydrogenase , NADP , 6-Phosphogluconate dehydrogenase , Catechin gallate , Glucose-6-phosphate dehydrogenase
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304189
Link To Document