Title of article
γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity Original Research Article
Author/Authors
Kumiko Sako، نويسنده , , Hiroshi Aoyama، نويسنده , , Shinichi Sato، نويسنده , , Yuichi Hashimoto، نويسنده , , Masanori Baba، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
11
From page
3780
To page
3790
Abstract
Based on anti-viral screening of our heteroaromatics derived from thalidomide, the γ-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-γ-carboline), with the EC50 of 0.26 μM.
Keywords
Anti-BVDV agents , ?-carboline , Thalidomide
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304209
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