Title of article
Ester derivatives of gallic acid with potential toxicity toward L1210 leukemia cells Original Research Article
Author/Authors
Claudriana Locatelli، نويسنده , , Rober Rosso، نويسنده , , Maria C. Santos-Silva، نويسنده , , Camila A. de Souza، نويسنده , , Marley A. Lic?nio، نويسنده , , Paulo Leal، نويسنده , , Maria L. Bazzo، نويسنده , , Rosendo A. Yunes، نويسنده , , Tânia B. Creczynski-Pasa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
9
From page
3791
To page
3799
Abstract
Gallic acid and gallates with the same number of hydroxyl groups and varying the length of the side carbon chain, with respective lipophilicity being defined through the C log P values, were examined for their ability to induce apoptosis (through the DNA ladder fragmentation pattern), mitochondrial and cytoplasmic GSH depletion and NF-κB activation in murine lymphoblastic L1210 leukemia cells. A relationship between cytotoxic effect and a limited degree of lipophilicity was observed.
Keywords
Leukemia , Lipophilicity , NF-?B , GSH , oxidative stress , apoptosis , Gallic acid ester derivatives
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304210
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