Title of article
Phosphonate-linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: Synthesis, DNA-binding affinity and cytotoxicity Original Research Article
Author/Authors
Ahmed Kamal، نويسنده , , P. Praveen Kumar، نويسنده , , B.N. Seshadri، نويسنده , , O. Srinivas، نويسنده , , M. Shiva Kumar، نويسنده , , Subrata Sen، نويسنده , , Nisha Kurian، نويسنده , , Aarti S. Juvekar، نويسنده , , Surekha M. Zingde، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
12
From page
3895
To page
3906
Abstract
Pyrrolobenzodiazepine-diethylphosphonate conjugates have been designed and synthesized that link through two different types of spacers that are simple alkane chain and also a piperazine moiety side-armed with the alkane chains. These pyrrolobenzodiazepine conjugates have exhibited remarkable DNA-binding affinity and improved solubility in water, a representative compound 7d showing promising in vitro cytotoxicity.
Keywords
Diethylphosphonate , DNA-binding affinity , Cytotoxicity , pyrrolobenzodiazepine
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304222
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