Author/Authors :
Stefanie Libnow، نويسنده , , Karen Methling، نويسنده , , Martin Hein، نويسنده , , Dirk Michalik، نويسنده , , Manuela Harms، نويسنده , , Kristian Wende، نويسنده , , Anke Flemming، نويسنده , , Martin K?ckerling، نويسنده , , Isolde Kommer, Helmut Reinke، نويسنده , , Patrick J. Bednarski، نويسنده , , Michael Lalk، نويسنده , , Peter Langer، نويسنده ,
Abstract :
The first indirubin-N′-glycosides were prepared based on reactions of isatin-N′-glycosides with indoxyls. The products show a significant anti-proliferative activity against various human cancer cell lines. Good results were observed for an indirubin-N′-mannoside which was shown to have medium to high anti-proliferative activity against all investigated cell lines. The highest activities and selectivities against the MCF-7 breast cancer cell line were observed for indirubin-N′-rhamnosides.
Keywords :
anti-proliferative activity , Carbohydrates , N-Heterocycles , Indirubin
