Title of article
Sulfadiazine/hydroxypropyl-β-cyclodextrin host–guest system: Characterization, phase-solubility and molecular modeling Original Research Article
Author/Authors
M?rcia Valéria Gaspar de Ara?jo، نويسنده , , Elze Kelly Barbosa Vieira، نويسنده , , Gilderman Silva L?zaro، نويسنده , , Leila Souza Conegero، نويسنده , , Luis Eduardo Almeida، نويسنده , , Ledjane Silva Barreto، نويسنده , , Nivan Bezerra da Costa Jr.، نويسنده , , Iara F. Gimenez، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
5788
To page
5794
Abstract
In this work we prepared and characterized an inclusion complex of the dihydropteroate synthase inhibitor sulfadiazine (SDZ) in 2-hydroxypropyl-β-cyclodextrin (HPBCD). From the phase-solubility diagram we observed an increase in the water solubility of the drug, calculating a binding constant of 1879 M−1. The inclusion mode involves a NH2-in orientation of the drug in the HPBCD cavity, according to the 2D NMR (ROESY) data and confirmed by molecular modeling using the semiempirical PM6 and RM1 methods.
Keywords
2-Hydroxypropyl-?-cyclodextrin , Sulfadiazine , Inclusion complex , Supramolecular , Toxoplasmosis
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304385
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