Title of article :
Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthetic analogues Original Research Article
Author/Authors :
Yutaka Aoyagi، نويسنده , , Yoshinao Takahashi، نويسنده , , Yudai Satake، نويسنده , , Koichi Takeya، نويسنده , , Ritsuo Aiyama، نويسنده , , Takeshi Matsuzaki، نويسنده , , Shusuke Hashimoto، نويسنده , , Teruo Kurihara، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Seven known abietane diterpenoids and 11-O- and 12-O-acetylcarnosic acids were isolated from a methanol extract of Perovskia abrotanoides (Labiatae). Structure and cytotoxic activity relationships (SAR) of the natural and semisynthetic analogues of the presently isolated abietane diterpenoids were studied by using P388 murine leukemia cells.
Keywords :
Carnosic acid , P388 murine leukemia cells , Semisynthesis , Cytotoxicity , Abietane diterpenoids , SAR
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
