Author/Authors :
Katrin Groebke Zbinden، نويسنده , , David W. Banner، نويسنده , , Kurt Hilpert، نويسنده , , Jacques Himber، نويسنده , , Thierry Lavé، نويسنده , , Markus A. Riederer، نويسنده , , Martin Stahl، نويسنده , , Thomas B. Tschopp، نويسنده , , Ulrike Obst-Sander، نويسنده ,
Abstract :
The discovery of a highly potent and selective tissue factor/factor VIIa inhibitor is described. Upon oral administration of its double prodrug in the guinea pig, a dose-dependent antithrombotic effect is observed in an established model of arterial thrombosis without prolonging bleeding time. The pharmacodynamic properties of this selective inhibitor are compared to the behaviour of a mixed factor VIIa/factor Xa inhibitor.
Keywords :
Anticoagulant , Coagulation cascade , Bleeding time prolongation , Double prodrug , Tissue factor/factor VIIa inhibitor
