Title of article
Discovery of new chemical leads for selective EP1 receptor antagonists Original Research Article
Author/Authors
Atsushi Naganawa، نويسنده , , Tetsuji Saito، نويسنده , , Yuuki Nagao، نويسنده , , Hiromu Egashira، نويسنده , , Maki Iwahashi، نويسنده , , Tohru Kambe، نويسنده , , Masatoshi Koketsu، نويسنده , , Hiroshi Yamamoto، نويسنده , , Michiyoshi Kobayashi، نويسنده , , Takayuki Maruyama، نويسنده , , Shuichi Ohuchida، نويسنده , , Hisao Nakai، نويسنده , , Kigen Kondo، نويسنده , , Masaaki Toda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
16
From page
5562
To page
5577
Abstract
A series of 4-({2-[alkyl(phenylsulfonyl)amino]phenoxy}methyl)benzoic acids were identified as functional PGE2 antagonists with selectivity for the EP1 receptor subtype starting from a chemical lead 1, which was found while screening our in-house compound library. Discovery of the optimized analogs 21–23 is presented here and structure–activity relationships (SAR) are also discussed.
Keywords
Prostaglandin , EP1 receptor , Antagonist , Sulfonamide
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304561
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