Title of article
New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents Original Research Article
Author/Authors
George N. Ziakas، نويسنده , , Eleni A. Rekka، نويسنده , , Antonios M. Gavalas، نويسنده , , Phaedra T. Eleftheriou، نويسنده , , Panos N. Kourounakis، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
9
From page
5616
To page
5624
Abstract
Amine or amide derivatives bearing the 2,6-di-tert-butyl phenol moiety are synthesised. Almost all are antioxidants, reduce acute inflammation and inhibit COX-1 and lipoxygenase activity. The most potent anti-inflammatory, COX-1 inhibitor and antioxidant agent, with low toxicity, is 2,6-di-tert-butyl-4-thiomorpholin-4-ylmethyl-phenol.
Keywords
Antioxidants , 2 , 6-Di-tert-butylphenol derivatives , anti-inflammatory agents , Cyclooxygenase , Lipoxygenase inhibition
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304566
Link To Document