Title of article
Synthesis of a novel potent cyclic peptide MC4-ligand by ring-closing metathesis Original Research Article
Author/Authors
Bas Wels، نويسنده , , John A.W. Kruijtzer، نويسنده , , Keith Garner، نويسنده , , Wouter A.J. Nijenhuis، نويسنده , , Willem Hendrik Gispen، نويسنده , , Roger A.H. Adan، نويسنده , , Rob M.J. Liskamp، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
7
From page
4221
To page
4227
Abstract
The synthesis of a novel potent cyclic peptide MC4-ligand by ring-closing metathesis (RCM) is described. Based on the Ac-Nle-Gly-Lys-d-Phe-Arg-Trp-Gly-NH2–MC4 ligand, Ac-Nle-Alg-Lys-d-Phe-Arg-Trp-Alg-NH2 was designed and synthesized followed by cyclization using RCM. Both compounds are high affinity and selective MC4-R-agonists. The cyclic RCM-peptide was more potent in a rat-grooming assay.
Keywords
MC4-agonists , cyclic peptide , Solid phase synthesis , Metathesis , Melanocortin
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304772
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