Title of article
Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent Original Research Article
Author/Authors
Takayoshi Suzuki، نويسنده , , Azusa Matsuura، نويسنده , , Akiyasu Kouketsu، نويسنده , , Shinya Hisakawa، نويسنده , , Hidehiko Nakagawa، نويسنده , , Naoki Miyata، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
11
From page
4332
To page
4342
Abstract
A series of suberoylanilide hydroxamic acid (SAHA)-based non-hydroxamates was designed, synthesized, and evaluated for their histone deacetylase (HDAC) inhibitory activity. Among these, methyl sulfoxide 15 inhibited HDACs in enzyme assays and caused hyperacetylation of histone H4 while not inducing the accumulation of acetylated α-tubulin in HCT116 cells.
Keywords
Histone deacetylase inhibitor , Non-hydroxamate
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304784
Link To Document