Title of article :
Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent Original Research Article
Author/Authors :
Takayoshi Suzuki، نويسنده , , Azusa Matsuura، نويسنده , , Akiyasu Kouketsu، نويسنده , , Shinya Hisakawa، نويسنده , , Hidehiko Nakagawa، نويسنده , , Naoki Miyata، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A series of suberoylanilide hydroxamic acid (SAHA)-based non-hydroxamates was designed, synthesized, and evaluated for their histone deacetylase (HDAC) inhibitory activity. Among these, methyl sulfoxide 15 inhibited HDACs in enzyme assays and caused hyperacetylation of histone H4 while not inducing the accumulation of acetylated α-tubulin in HCT116 cells.
Keywords :
Histone deacetylase inhibitor , Non-hydroxamate
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
