Title of article
Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents Original Research Article
Author/Authors
Anu Agarwal، نويسنده , , Kumkum Srivastava، نويسنده , , S.K. Puri، نويسنده , , Prem M.S. Chauhan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
4645
To page
4650
Abstract
A series of 2,4,6-trisubstituted-pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds have shown MIC in the range of 0.25–2 μg/mL. These compounds are in vitro severalfold more active than pyrimethamine.
Keywords
dihydrofolate reductase , antimalarial , Pyrimidine
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304816
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