Title of article
Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists Original Research Article
Author/Authors
Xueqing Wang، نويسنده , , Pramila A. Bhatia، نويسنده , , Jerome F. Daanen، نويسنده , , Steve P. Latsaw، نويسنده , , Jeffrey Rohde، نويسنده , , Teodozyi Kolasa، نويسنده , , Ahmed A. Hakeem، نويسنده , , Mark A. Matulenko، نويسنده , , Masaki Nakane، نويسنده , , Marie E. Uchic، نويسنده , , Loan N. Miller، نويسنده , , Renjie Chang، نويسنده , , Robert B. Moreland، نويسنده , , Jorge D. Brioni، نويسنده , , Andrew O. Stewart، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
12
From page
4667
To page
4678
Abstract
A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D4 agonists. The synthesis and structure–activity relationship (SAR) studies that led to the identification of these compounds are discussed.
Keywords
Dopamine D4 receptor , Agonist potency , Agonist efficacy , 3-Aryl piperidines
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304819
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