Title of article
Efficient synthesis of fluorothiosparfosic acid analogues with potential antitumoral activity Original Research Article
Author/Authors
Emmanuel Pfund، نويسنده , , Thierry Lequeux، نويسنده , , Serge Masson، نويسنده , , Michel Vazeux، نويسنده , , Alex Cordi، نويسنده , , Alain Pierre، نويسنده , , Valérie Serre، نويسنده , , Guy Hervé، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
8
From page
4921
To page
4928
Abstract
In this paper, we describe a short synthesis of N-(phosphonoacetyl)-l-aspartate (PALA) analogues. The mono- and difluorinated thioacetamide precursors were prepared in one step from methyl (diethoxyphosphono)di- and monofluoromethyldithioacetates 8 and 11 as starting materials. Antiproliferating properties on a L1210 strain and ATCase inhibition of these new compounds are disclosed. ThioPALA(FF) 5c showed a remarkable cytotoxic activity towards murine leukemia L1210, when used as tetraester.
Keywords
Sparfosic acid , ATCase , Difluorophosphonates , PALA , L1210
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304843
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