Title of article
Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate Original Research Article
Author/Authors
Yuqiang Wang، نويسنده , , Lianfa Li، نويسنده , , Wei Jiang، نويسنده , , James W. Larrick، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
8
From page
5592
To page
5599
Abstract
We have synthesized a conjugate of cis-4,7,10,13,16,19-docosahexenoic acid (DHA) and 10-hydroxycamptothecin (HCPT), DHA–HCPT. The antitumor activity of DHA–HCPT was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia, Lewis lung carcinoma, and colon 38 adenocarcinoma. DHA–HCPT showed a greatly improved antitumor efficacy compared to HCPT.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304907
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